![]() Food and Chemical Toxicology 1993 (31)5:331-5. system.17 The CYP3A4 isoenzyme is responsible for the metabolism of lovastatin, simvastatin, and atorvastatin. Journal of Food and Drug Analysis 2017 (25) 1:71-83. One study showed that drinking a glass of grapefruit juice with simvastatin or lovastatin increased blood levels of these statins by 260 ( 5 ). ![]() Chemistry and health effects of furanocoumarins in grapefruit. 19 The inhibition of first-pass metabolism of lovastatin or simvastatin could result in 1020-fold elevations (oral bioavailability increasing from 5 to 100) in steady-state. Grapefruit juice and any grapefruit products should be avoided, as should large quantities of limes or lime peel, although small amounts (such as a twist of lime in a drink) are unlikely to cause a significant interaction. Grapefruit juice inhibits CYP enzymes in the intestinal mucosa and liver and increased toxicity has been observed when statins have been consumed with grapefruit juice. Out of all the statins, atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Altoprev) have the strongest interaction with grapefruit, and this is likely to be true for other citrus. Unfortunately, in humans, furanocoumarins block one of the main liver enzymes involved in the metabolism of some statins, called CYP3A4, which could lead to increased blood levels of the interacting drug, leading to more severe side effects, including muscle pain. Limes, lemons, and bergamot also contain bergamottin, with limes reported to contain the highest amount, especially peel. Grapefruit juice inhibits the CYP3A4 enzyme of the cytochrome P450 system in. Research has previously identified bergamottin as the main statin-interacting substance in grapefruit. Grapefruit juice greatly increased serum concentrations of simvastatin and simvastatin acid and, to a lesser extent, those of active and total HMG-CoA reductase inhibitors. Lipitor drug interactions grapefruit Concomitant administration of LIPITOR. The major furanocoumarins found in grapefruit include bergamottin, epoxybergamottin, and 6′,7′-dihydroxybergamottin. Grapefruit, limes, and other citrus fruits contain furanocoumarins, which are compounds that help protect the fruit from certain insects and infections. There just hasn't been as much research published regarding how other types of citrus (apart from grapefruit) interact with statins. Limes, pomegranates, pomelos, and Seville oranges can also interact with some medications, including statins such as atorvastatin.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |